The Best CBD Oil for Anxiety, Stress, and Depression in 2023 – WRTV Indianapolis

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If you often experience symptoms of excessive and irrational fear, worry, and apprehension, there are steps you can take to feel better. Many anxiety symptoms can be alleviated by using natural therapies, such as CBD-based wellness products.
We review the best CBD oils for anxiety to help you find one that suits you. We’ll also talk about choosing the best CBD oil and exploring the research behind using CBD for anxiety 
 
 
Anxiety disorders are becoming more prevalent due to stress from work, health concerns, and financial commitments. Studies show that CBD oil may help treat anxiety and alleviate depression by altering serotonin levels in the brain [1]. Here are our top choices. 
 

Start with organic farming practices, and you’ll get the highest-quality hemp—that is the philosophy behind Cornbread Hemp, a firm founded on Kentucky’s 250-year hemp legacy. 
Cornbread Hemp’s products are USDA-certified organic and manufactured with hemp flowers only—no stems, stalks, leaves, or seeds. Once the flowers are separated from the stalks, they undergo organic sugarcane ethanol extraction, with no further processing, keeping all the hemp goodness in the formula.
Cornbread Hemp’s website has third-party certificates of analysis (COAs) from ISO 17025-certified labs readily available. If you wish to get results for a specific product, you can search by batch number or study the COAs for all items before making a purchase, this includes CBD creams.
 
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Who Is Cornbread Hemp Best For?
Cornbread Hemp’s Full Spectrum CBD Oil is beneficial for everyday stress alleviation, muscle and joint relaxation, maintaining a functioning sleep schedule, and overall well-being. 
With Whole Flower (25mg of CBD to 1mg of THC) and Distilled (50mg of CBD to 1mg of THC) extracts, you can use the Whole Flower extract for improved sleep and the Distilled extract to stay calm, yet alert throughout the day.
 
Who Should Avoid Cornbread Hemp?
If you are pregnant, nursing, using drugs, or have serious medical conditions, consult your primary care physician before using this product.
 
Potential Side Effects
 
Summary
Cornbread Hemp is a high-quality CBD oil that uses only hemp flowers to maximize its therapeutic effects. However, consult your healthcare provider to see whether Cornbread Hemp can help you control your anxiety. 
>> Check the best price for Cornbread Hemp
 

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Who Is Spruce Best For?
Spruce is best for you if you need immediate relaxation. With the specifications of 750mg and 2,400mg in potency, anxiety sufferers report that the oil is effective, helps deliver the strongest relief possible, and improves their sleep.
Research also shows that full-spectrum organic hemp CBD oils, such as Spruce, are beneficial in treating pain and inflammatory diseases [2]. This means that each dropper of Spruce has multiple therapeutic properties that can provide immediate and long-term pain relief—essential for those suffering from chronic pain.
 
Who Should Avoid Spruce?
It is best to avoid all THC consumption, Spruce included, if you regularly undergo drug testing or are pregnant. 
 
Potential Side Effects
 
Summary
Spruce offers pure CBD oil products that have been tested by a third-party lab. Customers may view the lab findings for the company’s CBD products online, ensuring they purchase a pure, third-party-tested product. In addition, their products are pesticide-free, and do not include heavy metals or biotoxins.
>> Check the best price for Spruce
 

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Who Is Pet Best For?
Pet’s gluten- and GMO-free hemp seed oil is ideal if your dog is stressed from thunderstorms, fireworks, socializing with other dogs or humans, visiting the vet, or traveling. 
 
Who Should Avoid Pet?
Pet CBD oil should not be used if your dog has been diagnosed with low blood pressure or hypotension. If your pet has been diagnosed with hypotension or it has been a while since their last blood pressure check, make an appointment with your veterinarian.
 
Potential Side Effects
 
Summary
Pet CBD is proud of its all-natural, well-formulated solutions and cutting-edge technologies. The brand produces its oils using only the finest all-organic hemp grown in Colorado and does frequent internal and external lab evaluations to ensure the quality. It’s also the best CBD oil for dogs.
>> Check the best price for Pet CBD
 

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Who Is NuLeaf Naturals Best For?
If you have trouble sleeping, NuLeaf Naturals CBD could be the oil for you. 
As a whole-plant extract, this high-quality CBD oil contains the complete spectrum of cannabinoids and terpenes, making it a helpful remedy for sound sleep. 
Research shows terpenes have natural calming and hypnotic properties [3]. Additionally, the oil may help to alleviate brain stress by enhancing memory and reducing brain fog.
 
Who Should Avoid NuLeaf Naturals?
Some drugs, such as blood thinners, may interfere with the CBD in NuLeaf. Consequently, it’s critical to see your doctor before taking this supplement.
 
Potential Side Effects 
 
Summary
NuLeaf Naturals CBD oil products are formulated with all-natural, organic, and non-toxic components. The oil has all of the necessary elements to promote brain and body relaxation and tranquility.
>> Check the best price for NuLeaf Naturals
 

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Who Is Vital Plan Select Best For?
With its innovative thermal extraction technology, which aims to optimize terpene content, Vital Plan Select can help alleviate the frequently agonizing symptoms that migraine sufferers experience.
A 2018 study found that cannabinoids and other constituents like terpenes—the natural compounds in the cannabis plant’s flower or bud—have great potential to relieve headache and migraine pain [10].
 
Who Should Avoid Vital Plan?
Vital Plan contains a low level of THC, making it unsuitable if you must undergo regular drug tests. 
 
Potential Side Effects
 
Summary
Vital Plan is a terpene-rich CBD oil that provides you with the best of the entourage effect. Thanks to this synergistic, anti-inflammatory effect, you may find relief from painful conditions such as migraine. 
>> Check the best price for Vital Plan
 

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Who Is Charlotte’s Web Best For?
Charlotte’s Web is a good choice if you’re new to taking CBD, with dosages starting from as little as 7mg. If anxiety and stress keep you awake, this oil could be the right choice for you, with clinical studies confirming the beneficial effects of Charlotte’s Web hemp plant extract on stress, sleep, and general well-being [4].
 
Who Should Avoid Charlotte’s Web?
Charlotte’s Web is high in the sedative terpene myrcene, which you should avoid if you already take sedatives or experience fatigue. 
 
Potential Side Effects
 
Summary
Charlotte’s Web is a distributor of hemp and cannabidiol products known for their high-quality and all-natural components. The company offers a diverse selection of CBD oils, capsules, CBD creams, and other hemp-derived products that may help with exercise-induced inflammation, sleep cycles, daily stress, calm, and focus.
>> Check the best price for Charlotte’s Web
 

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Who Is Medterra CBD Oil Best For?
Medterra could be right for you if you must completely avoid THC. Medterra CBD oil has many benefits, one of the most essential being its capacity to regulate our endocannabinoid system.
The unique 1:1 blend of CBD and CBG may benefit patients seeking to treat pain, especially neuropathic pain [5].
 
Who Should Avoid Medterra CBD Oil?
High-potency CBD oil may not be suitable if you take other sedative herbs or drugs or certain medications such as warfarin or lithium. 
 
Potential Side Effects
 
Summary
Medterra offers CBD extracts sourced from certified organic hemp. The oils combine CBD, MCT, and natural flavors, offering support for mental and physical health.
>> Check the best price for Medterra CBD Oil
 

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Who Is Lazarus Naturals Best For?
At just 2 to 3 cents per mg of CBD, Lazarus Naturals gives you the best value for money, making it suitable for those on a budget.
Customer reviews show glowing remarks, with many saying the oil has helped them achieve a sense of calm, peace, and balance, improving their emotional well-being and general health.
The brand claims its full-spectrum tinctures offer effective combinations of active ingredients and organically derived fruit flavors such as Yuzu’s Japanese citrus flavor. In a study, Yuzu was found to have stress-relieving aromatherapeutic qualities, along with antioxidant, anticarcinogenic, anti-inflammatory, and anti-diabetic properties [6].
 
Who Should Avoid Lazarus Naturals?
Before using Lazarus Naturals High Potency CBD Tincture Yuzu, inform your doctor of all medications you are currently taking, including prescription and over-the-counter. Citrus fruits can affect how your medicines work by increasing or decreasing their effects [7].
 
Potential Side Effects
 
Summary
Lazarus Naturals offers excellent value for money with its CBD oil—2,400mg—presently available for $60. This equates to a $0.025 cost per mg, less than other big brands in the CBD industry.  
>> Check the best price for Lazarus Naturals
 

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Who Is Absolute Nature CBD Best For?
Absolute Nature CBD oil offers multiple potential therapeutic effects, such as stress relief, pain management, support for better sleep quality, and treating insomnia. 
The company offers a 100% money-back guarantee on all of its products. Customers dissatisfied with their purchase can return the unused product within 30 days and obtain a full refund. You can also return open products within 14 days of delivery. 
 
Who Should Avoid Absolute Nature CBD?
If you are taking sedatives or muscle relaxants, Absolute Nature CBD may have an additive effect, so use caution or avoid the product. 
 
Potential Side Effects
 
Summary
Absolute Nature offers a range of CBD products that are 100% natural, vegan, eco-friendly, and third-party lab tested. 
>> Check the best price for Absolute Nature
 

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Who Is Fab CBD Best For?
Fab CBD products might be a good choice if you have hypertension. For instance, the Fab CBD Sleep Gummies contain L-theanine, which has been shown to lower blood pressure in laboratory research [8].
Additionally, CBD itself has been shown to have vasodilator properties, which benefit hypertensive patients by increasing the width of arteries [9].
 
Who Should Avoid Fab CBD?
With only full-spectrum options available, Fab CBD is best avoided if you must stick to zero-THC extracts. Supply issues may affect you if you cannot miss a dose. 
 
Potential Side Effects
 
Summary: 
CBD products may lower hypertension and its symptoms, such as chest pain, headache, and trouble sleeping. With high concentrations of CBD and the inclusion of other ingredients, such as L-theanine, in some products, you may find effective relief from anxiety and related issues. 
 
Approximately 40 million adults in the United States are estimated to be affected by anxiety disorders, the most frequent type of mental illness [11]. 
CBD, a cannabinoid in the Cannabis sativa plant, is a non-psychoactive chemical that can treat anxiety disorders. However, any cannabis plant containing more than 0.3% THC is classified as marijuana under federal law and, therefore, does not receive legal protection under this legislation. 
Consult your healthcare provider to see whether CBD oils can help you control your anxiety.
>> Check the best price for Cornbread Hemp
 
The central nervous system is densely packed with cannabinoid receptors; they influence the functioning of our brain cells by regulating the release of neurotransmitters. Deficiencies in natural cannabinoids may increase the risk of developing PTSD and depression [12].
According to the authors of a 2015 research, CBD interacts with the cannabinoid type 1 receptor (CB1R), the serotonin 5-HT1A receptor, and other brain receptors that regulate fear and anxiety-related behaviors [13]. As demonstrated by these findings, CBD may have potential as a treatment for acute anxiety symptoms.
Preclinical and clinical evidence also supported CBD’s efficacy in treating many anxiety disorders, including:
Does Adderall help with anxiety? Find out here.
 
CBD’s immediate effects typically take 30 to 120 minutes to take effect. However, long-term effects may take several weeks to manifest themselves.
It turns out that CBD is not a one-size-fits-all solution. Numerous variables—including your dose, the form (full-spectrum CBD oil, broad-spectrum CBD oil, or CBD isolate), and weight—can impact how long it takes for CBD to begin working. 
 
The entourage effect refers to the heightened benefits of CBD when numerous compounds work synergistically rather than alone.
Monoterpenes, diterpenes, triterpenes, and sesquiterpenes are all key components in cannabis resin that give it its distinct aroma. They can also alter the therapeutic qualities of different cannabis chemotypes due to their capacity to quickly permeate cell membranes and the blood-brain barrier [14].
 
CBD’s potential to alleviate anxiety may follow what scientists refer to as a “dose-response curve.” Simply put, the curve depicts the relationship between dose size and response.
A study found that higher doses of CBD are more effective at reducing anxiety—but not too high [15]. Before a public speaking exam, the researchers gave participants varied CBD dosages. A 300mg dose of CBD significantly reduced subjective anxiety markers. This decline did not occur with the 150mg, 600mg, or placebo CBD dosages.
 
The amount of CBD you need to take to reap the advantages is directly proportional to your body fat. People who are overweight will require a higher dose of CBD oil to feel the effects, and body fat will also influence how long CBD lingers in your system. 
While CBD does not need to build up in your body to work, however, it does become stored in fat cells and will stay in your body even after the effects of CBD have worn off. 
>> Check the best price for Cornbread Hemp
 
CBD is a more natural alternative to pharmaceutical anxiety medications. Many CBD products come from certified organic hemp plants, grown and cultivated without pesticides or herbicides.
Conventional anti-anxiety medications are frequently seen on lists of the most commonly abused pharmaceuticals. Due to the euphoric feelings they often induce, users may quickly develop tolerance and, as a result, become more reliant on use to maintain control of their anxiety. 
According to one study, taking drugs to treat insomnia and anxiety raises the risk of death by 36% [16].
Furthermore, the correct diagnosis of an anxiety condition is the first step toward treatment.  If the initial treatment is unsuccessful and someone receives a wrong diagnosis, the repercussions can be catastrophic, depending on the underlying illness [17]. 
Receiving the wrong treatment can also result in a person suffering all of the medication’s negative effects while receiving none of the benefits, creating unnecessary distress and worry while leaving the underlying problem unaffected.
 
CBD products come with risks and benefits, which are essential to be aware of before use. 
 
CBD may benefit several symptoms related to anxiety:
Besides legal issues, we ensured that every CBD oil reviewed here does not have a high enough THC:CBD ratio to cause anxiety. 
>> Check the best price for Cornbread Hemp
 
CBD is considered safe and well-tolerated by the World Health Organization [19]. However, it does have some adverse effects, including:
Pregnant or breastfeeding women should avoid using any cannabis product, including CBD.
Additionally, CBD products may potentially enhance the risk of adverse effects when combined with certain medications. 
Some regularly prescribed medicines, such as warfarin, lithium, sertraline, tramadol, codeine, valproic acid, carbamazepine, and captopril, may cause interactions. Consult your doctor before using CBD with other drugs to avoid interactions.
 
When picking a CBD oil for anxiety, it is important to research to ensure that you receive the most up-to-date and accurate information regarding high-quality CBD oils. 
Here are some things to consider:
 
For anxiety, the optimal THC:CBD ratio is 1:1, with one or more parts CBD to each part THC. When the THC:CBD ratio is greater than 1:1, anxiety may be exacerbated.
When CBD and THC are used together, they have a lot of coactions. In recent years, there has been a rising interest in determining the optimal ratio of each cannabinoid for treating various health issues, including anxiety disorders. Before buying, consider that THC-dominant concentrates induce euphoria and sedation, so care needs to be taken.
 
No matter what condition you’re aiming to treat with CBD, giving yourself an adequate dosage is important. Otherwise, it may not be effective. As previously reported, using a 300mg dosage of CBD was found to lower subjective anxiety signs significantly.
 
In today’s market, third-party CBD testing is critical. A survey found that over 70% of cannabidiol extracts sold online are mislabeled, containing significantly more or less CBD than advertised [20]. 
The goal of third-party or independent lab testing is to give an objective assessment of CBD oil brands. These tests determine a CBD sample’s quality, purity, and potency. 
 
Given that CBD is a supplement that people use regularly, there are concerns about the potential of developing tolerance.
However, regular CBD users do not appear to develop a tolerance. This is because CBD and THC bind to CB1 receptors in different ways. As a result, CBD does not desensitize these receptors when it binds to them.
>> Check the best price for Cornbread Hemp
 
CBD oil for anxiety can be consumed in various ways:
Keep in mind that if you put your CBD oil in a smoothie or a coffee with almond milk, sugar, or anything else that needs to be digested, it will take longer for the CBD to kick in than if you put a few drops under your tongue. 
 
Cornbread’s Pet CBD Oil is the product we found to be the best CBD oil for dogs and cats with anxiety.
Dogs, like humans, have an endocannabinoid system that includes cannabinoid receptors and endocannabinoids. This means they can benefit from organic CBD oil in the same way that humans do. CBD works by attaching to cannabinoid receptors, allowing natural equilibrium and creating a state of balance inside the body. 
Many ailments can be alleviated with this balance, including anxiety. Consequently, CBD dog treats are an all-natural solution that can benefit your four-legged friend’s health and well-being for years to come. 
 
A dose between 1 and 5mg for every 10 lbs of body weight is generally recommended for dogs with anxiety.
Consider a dose in the midpoint of the recommended range and keep an eye out for sedative effects. Within an hour, you should notice a difference. If not, you may wish to provide additional CBD to bring the whole dose to the recommended maximum.
Once you’ve administered the correct dose, your dog should not appear lethargic; rather, it should appear calmer with less panting, pacing, and whining. 
>> Check the best price for Cornbread Hemp
 
Drug tests do not screen for cannabidiol. However, many CBD products contain trace amounts of THC, marijuana’s primary active component. If sufficient THC is present, it will be detected on a drug test. This begs the question: Is CBD legal?
CBD products having greater than 0.3% THC are classified as marijuana under federal law but are legal under certain state regulations. Always verify state legislation, particularly when traveling. Additionally, remember that the FDA has not approved nonprescription CBD products and that some products may be labeled incorrectly. 
 
We weighed the benefits and drawbacks of each CBD brand and oil product on the market to pick the best CBD for anxiety. We focused on nine criteria to rank each product in an unbiased, transparent, and accurate manner. 
 
The results of a 2019 case study, which included 103 adults, revealed that CBD is beneficial in reducing self-reported anxiety.
In a double-blind trial, participants were randomly assigned to receive oral CBD at 150 mg, 300 mg, 600 mg, or placebo doses. A 300 mg dose of CBD oil was found to reduce anxiety symptoms considerably [18]. 
 
A study by researchers from the University of Pennsylvania School of Medicine found that approximately 70% of all CBD oil brands marketed online are mislabeled or contain hazardous amounts of THC, posing a major risk to patients and consumers [20].
Because a third-party company is less likely to mislead on its lab tests, this technique boosts a CBD manufacturer’s credibility. Many of these businesses are well-known in the industry, and they have a reputation to uphold by doing regular, accurate testing. 
 
CBD oils of high grade are derived from organically-produced hemp. According to a review of most CBD oils, only a handful of CBD oils are certified organic by credible agencies like the USDA.
 
The best CBD oils for anxiety disorders are produced by trained experts such as pharmacists, doctors, and other licensed professionals. Companies that have such expertise in their workforce are generally trustworthy.
Additionally, we combed through reviews of candidates for the best CBD oil for anxiety on various websites, including the company’s website and various social media platforms.
 
THC and CBD appear to have different impacts on anxiety disorders. Pure THC reduces anxiety at low dosages while increasing anxiety at high doses. Products with a 1:1 ratio have minor psychoactive effects and can be extremely efficient at reducing the symptoms of anxiety disorders. 
These products allow the customer to benefit from THC’s more intense calming benefits while reducing the risk of experiencing THC’s negative effects.
 
Carrier oil is critical for increasing the potency of CBD oils. Although many CBD oils and other CBD products are water-based, some companies add MCTs and other fatty oils. Carrier oils boost CBD oil quality, absorption, and delivery. As a result, they are an important feature to consider when rating CBD oils.
 
Broad-spectrum CBD oil and CBD isolate enable users to reap the benefits of CBD’s effects in combination with other forms of cannabis extract. However, neither of these options utilizes all of the beneficial qualities inherent in the cannabis plant to the extent that full-spectrum CBD oils do.
 
In addition to CBD and THC, the cannabis plant includes over 100 cannabinoids and a slew of other terpenes and flavonoids. 
For example, full-spectrum hemp extract CBD oil will include all-natural hemp constituents such as aromatic terpenes, which enhance the effects of CBD and other cannabinoids, flavonoids, omega acids, phytonutrients, and phytocannabinoids like CBG and CBC.
 
Without flavorings, CBD oil has an earthy, grassy flavor, which is why manufacturers are creating a variety of flavored CBD oils to improve the product’s taste. Top-rated CBD companies use flavors approved by the USDA Organic standards.
>> Check the best price for Cornbread Hemp
 
Here are the answers to some of the most frequently asked questions about CBD oil for anxiety.
 
Yes, preliminary evidence from human trials, including both healthy volunteers and people suffering from a social anxiety disorder, suggests that CBD has anxiolytic properties. As a result, it can be used as a potential treatment for generalized anxiety disorder, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, and social anxiety disorder.
 
Sublingually administered (under the tongue) CBD oil, like Cornbread Hemp, is the most effective form of CBD for anxiety, having the highest and fastest absorption rate of the cannabinoid.
 
Cornbread, Spruce, and Nuleaf would be our top recommendations, informed by our research. For pets with anxiety, Pet CBD Oil is uniquely suited to ease the symptoms without ‘zombie-Ying out’ your pet.
CBD oil effectively treats various mental disorders, such as anxiety, panic, OCD, and more. However, choosing the right oil for you, with the correct THC:CBD ratio is crucial to get the most out of the oil without the negative effects of THC.
All of the CBD oil for anxiety we included in our list are certified organic, and third-party lab tested to ensure maximum quality. Remember that if you often undergo drug testing, choosing a THC-free CBD oil is essential, otherwise, you risk testing positive for marijuana.
>> Check the best price for Cornbread Hemp
 
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